GHK-Cu (Copper Peptide) FAQs

GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper) is a naturally occurring peptide that binds with copper ions. Its levels decline with age, and it is primarily used for its regenerative and anti-aging properties.

What is GHK-Cu and how does it work?

It is a copper-binding tripeptide that is naturally present in your body. It works by modulating gene expression (affecting over 4,000 genes), promoting tissue regeneration, stimulating collagen and elastin production, and possessing strong anti-inflammatory and antioxidant effects.

What are the primary injectable benefits?

In its injectable/systemic form, GHK-Cu is sought after for anti-aging, skin health (improved elasticity, density, and reduced wrinkles), hair growth (by stimulating follicles and improving blood flow), and accelerated wound/tissue healing.

How is it typically administered?

Typically administered as a subcutaneous injection (under the skin) using a small insulin needle. Protocols vary, often involving a cycling schedule (e.g., 30-60 days on, followed by an equal period off) to maintain receptor sensitivity and prevent potential copper dysregulation.

What are the common side effects?

Generally well-tolerated. The most common injectable side effects are localized reactions like redness, mild pain, or swelling at the injection site, or sometimes mild fatigue, dizziness, or a metallic taste in the mouth.

Why is the "Cu" important?

The GHK-Cu complex (peptide bound to a copper ion) is the biologically active form responsible for its regenerative effects. GHK alone is less stable and less effective than the copper-bound complex.Is it safe for long-term use?GHK-Cu has a favorable safety profile and does not appear to lead to tolerance. However, due to its copper content, cycling the therapy under medical supervision is often recommended for long-term use to prevent theoretical copper overload.

What is NAD+ and how does it work?

NAD+ is a coenzyme essential for cellular energy production (fueling mitochondria), DNA repair, and regulating metabolism and sirtuin activity (proteins linked to longevity). Restoring declining NAD+ levels supports overall cellular health and vitality.

What are the primary injectable benefits?

The main benefits reported are increased energy levels, enhanced mental clarity (reduced "brain fog"), improved focus and mood, faster muscle recovery, and support for healthy aging and cellular repair processes.How are injections different from oral supplements?Injections (Subcutaneous, Intramuscular, or IV) bypass the digestive system, resulting in higher bioavailability (more of the dose reaches the cells) and often faster, more noticeable effects compared to oral supplements.

How often should I inject NAD+?

Dosing protocols vary significantly based on individual goals and the supervising clinician. Common protocols range from 3-5 injections per week during a loading phase, followed by monthly maintenance shots.

What are the common side effects?

Side effects are usually mild and temporary, often related to the infusion/injection speed. They can include mild flushing or warmth (a "niacin flush"), temporary nausea, headache, or tenderness/redness at the injection site. Slowing the administration rate usually mitigates these effects.

Who should avoid NAD+ injections?

NAD+ is generally considered safe but is typically not recommended for individuals who are pregnant or breastfeeding, have active cancer, or have severe liver/kidney disease without specialized medical guidance.